A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics

J. B. Wright; I. Brener; K. R. Westlake; D. W. Branch; M. J. Shaw; G. A. Vawter

doi:10.1117/12.842283

A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics

J. B. Wright
, I. Brener
, K. R. Westlake
, D. W. Branch
, M. J. Shaw
, G. A. Vawter

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Scopus citations

Abstract

We demonstrate chemical/biological sensor arrays based on high quality factor evanescent microring waveguide resonators in a process that is compatible with CMOS fabrication, glass microfluidic integration, and robust surface chemistry ligand attachment. We cancel out any fluctuations due to liquid temperature variations through a differential dual sensor design. Using laser locking servo techniques we attain detection sensitivities in the ng/ml range. This combination of silicon photonic sensors, robust packaging, high sensitivity and arrayed design is capable of providing a platform for multiplexed chem-bio sensing of molecules suspended in solution. © 2010 Copyright SPIE - The International Society for Optical Engineering.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Volume	7605
DOIs	https://doi.org/10.1117/12.842283
State	Published - May 3 2010
Externally published	Yes

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@inproceedings{e7aae107b29c467bb8df62d441e572a3,

title = "A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics",

abstract = "We demonstrate chemical/biological sensor arrays based on high quality factor evanescent microring waveguide resonators in a process that is compatible with CMOS fabrication, glass microfluidic integration, and robust surface chemistry ligand attachment. We cancel out any fluctuations due to liquid temperature variations through a differential dual sensor design. Using laser locking servo techniques we attain detection sensitivities in the ng/ml range. This combination of silicon photonic sensors, robust packaging, high sensitivity and arrayed design is capable of providing a platform for multiplexed chem-bio sensing of molecules suspended in solution. {\textcopyright} 2010 Copyright SPIE - The International Society for Optical Engineering.",

author = "Wright, \{J. B.\} and I. Brener and Westlake, \{K. R.\} and Branch, \{D. W.\} and Shaw, \{M. J.\} and Vawter, \{G. A.\}",

year = "2010",

month = may,

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doi = "10.1117/12.842283",

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isbn = "9780819480019",

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A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics. / Wright, J. B.; Brener, I.; Westlake, K. R. et al.
Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7605 2010.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics

AU - Wright, J. B.

AU - Brener, I.

AU - Westlake, K. R.

AU - Branch, D. W.

AU - Shaw, M. J.

AU - Vawter, G. A.

PY - 2010/5/3

Y1 - 2010/5/3

N2 - We demonstrate chemical/biological sensor arrays based on high quality factor evanescent microring waveguide resonators in a process that is compatible with CMOS fabrication, glass microfluidic integration, and robust surface chemistry ligand attachment. We cancel out any fluctuations due to liquid temperature variations through a differential dual sensor design. Using laser locking servo techniques we attain detection sensitivities in the ng/ml range. This combination of silicon photonic sensors, robust packaging, high sensitivity and arrayed design is capable of providing a platform for multiplexed chem-bio sensing of molecules suspended in solution. © 2010 Copyright SPIE - The International Society for Optical Engineering.

AB - We demonstrate chemical/biological sensor arrays based on high quality factor evanescent microring waveguide resonators in a process that is compatible with CMOS fabrication, glass microfluidic integration, and robust surface chemistry ligand attachment. We cancel out any fluctuations due to liquid temperature variations through a differential dual sensor design. Using laser locking servo techniques we attain detection sensitivities in the ng/ml range. This combination of silicon photonic sensors, robust packaging, high sensitivity and arrayed design is capable of providing a platform for multiplexed chem-bio sensing of molecules suspended in solution. © 2010 Copyright SPIE - The International Society for Optical Engineering.

UR - https://www.scopus.com/pages/publications/77951542339

U2 - 10.1117/12.842283

DO - 10.1117/12.842283

M3 - Conference contribution

SN - 9780819480019

VL - 7605

BT - Proceedings of SPIE - The International Society for Optical Engineering

ER -

A platform for multiplexed sensing of biomolecules using high-Q microring resonator arrays with differential readout and integrated microfluidics

Abstract

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