Active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay

George D. Bachand; Susan B. Rivera; Amanda Carroll-Portillo; Henry Hess; Marlene Bachand

doi:10.1002/smll.200500262

Active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay

George D. Bachand
, Susan B. Rivera
, Amanda Carroll-Portillo
, Henry Hess
, Marlene Bachand

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The technique of active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay was described. Nanofluidic transport of macromolecules within living cells is achieved using a complex, three-dimensional network of cytoskeletal filaments and motor proteins. It is observed that glutaraldehyde crosslinking successfully linked fluorescent antibodies to MT shuttles. The application of kinesin and Ab-MT as mechanical actuators enables the development of nanofluidic systems that rely only on chemical energy for capturing and separating of target analytes from a complex solution.

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Small
Volume	2
Issue number	3
DOIs	https://doi.org/10.1002/smll.200500262
State	Published - Mar 1 2006
Externally published	Yes

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10.1002/smll.200500262

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abstract = "The technique of active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay was described. Nanofluidic transport of macromolecules within living cells is achieved using a complex, three-dimensional network of cytoskeletal filaments and motor proteins. It is observed that glutaraldehyde crosslinking successfully linked fluorescent antibodies to MT shuttles. The application of kinesin and Ab-MT as mechanical actuators enables the development of nanofluidic systems that rely only on chemical energy for capturing and separating of target analytes from a complex solution.",

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AU - Bachand, George D.

AU - Rivera, Susan B.

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AU - Hess, Henry

AU - Bachand, Marlene

PY - 2006/3/1

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AB - The technique of active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay was described. Nanofluidic transport of macromolecules within living cells is achieved using a complex, three-dimensional network of cytoskeletal filaments and motor proteins. It is observed that glutaraldehyde crosslinking successfully linked fluorescent antibodies to MT shuttles. The application of kinesin and Ab-MT as mechanical actuators enables the development of nanofluidic systems that rely only on chemical energy for capturing and separating of target analytes from a complex solution.

UR - https://www.scopus.com/pages/publications/32344445070

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Active capture and transport of virus particles using a biomolecular motor-driven, nanoscale antibody sandwich assay

Abstract

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