Characterizing the function of unstructured proteins: Simulations of charged polymers under confinement

Joanne N. Bright; Mark J. Stevens; Jan Hoh; Thomas B. Woolf

doi:10.1063/1.1392361

Characterizing the function of unstructured proteins: Simulations of charged polymers under confinement

Joanne N. Bright
, Mark J. Stevens
, Jan Hoh
, Thomas B. Woolf

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Molecular dynamics (MD) simulations of neutral, charged and polyampholyte polymers within a confined geometry were performed. The simulations provided a good test of polymer predictions for finite length chains. Furthermore, these simulations suggest a previously unexplored dependence of the properties of a tethered, confined polyampholyte on the charge sequence of the chain.

Original language	English
Pages (from-to)	4909-4918
Number of pages	10
Journal	Journal of Chemical Physics
Volume	115
Issue number	10
DOIs	https://doi.org/10.1063/1.1392361
State	Published - Sep 8 2001
Externally published	Yes

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title = "Characterizing the function of unstructured proteins: Simulations of charged polymers under confinement",

abstract = "Molecular dynamics (MD) simulations of neutral, charged and polyampholyte polymers within a confined geometry were performed. The simulations provided a good test of polymer predictions for finite length chains. Furthermore, these simulations suggest a previously unexplored dependence of the properties of a tethered, confined polyampholyte on the charge sequence of the chain.",

author = "Bright, \{Joanne N.\} and Stevens, \{Mark J.\} and Jan Hoh and Woolf, \{Thomas B.\}",

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T1 - Characterizing the function of unstructured proteins: Simulations of charged polymers under confinement

AU - Bright, Joanne N.

AU - Stevens, Mark J.

AU - Hoh, Jan

AU - Woolf, Thomas B.

PY - 2001/9/8

Y1 - 2001/9/8

N2 - Molecular dynamics (MD) simulations of neutral, charged and polyampholyte polymers within a confined geometry were performed. The simulations provided a good test of polymer predictions for finite length chains. Furthermore, these simulations suggest a previously unexplored dependence of the properties of a tethered, confined polyampholyte on the charge sequence of the chain.

AB - Molecular dynamics (MD) simulations of neutral, charged and polyampholyte polymers within a confined geometry were performed. The simulations provided a good test of polymer predictions for finite length chains. Furthermore, these simulations suggest a previously unexplored dependence of the properties of a tethered, confined polyampholyte on the charge sequence of the chain.

UR - https://www.scopus.com/pages/publications/0035828344

U2 - 10.1063/1.1392361

DO - 10.1063/1.1392361

M3 - Article

SN - 0021-9606

VL - 115

SP - 4909

EP - 4918

JO - Journal of Chemical Physics

JF - Journal of Chemical Physics

IS - 10

ER -

Characterizing the function of unstructured proteins: Simulations of charged polymers under confinement

Abstract

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