Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung

Leisha M. Armijo; Yekaterina I. Brandt; Nathan J. Withers; John B. Plumley; Nathaniel C. Cook; Antonio C. Rivera; Surabhi Yadav; Gennady A. Smolyakov; Todd Monson; Dale L. Huber; Hugh D.C. Smyth; Marek Osiński

doi:10.1117/12.913577

Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung

Leisha M. Armijo
, Yekaterina I. Brandt
, Nathan J. Withers
, John B. Plumley
, Nathaniel C. Cook
, Antonio C. Rivera
, Surabhi Yadav
, Gennady A. Smolyakov
, Todd Monson
, Dale L. Huber
, Hugh D.C. Smyth
, Marek Osiński

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Iron oxide colloidal nanocrystals (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanocrystals to increase the effectiveness of inhalation aerosol antibiotics therapy through two mechanisms: directed particle movement in the presence of a static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm thereby increasing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Nanocrystals in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide-zinc selenide core-shell nanoparticles were prepared in parallel in order to allow imaging of the iron oxide nanoparticles. © 2012 SPIE.

Original language	English
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8232
DOIs	https://doi.org/10.1117/12.913577
State	Published - Apr 2 2012
Externally published	Yes

Access to Document

10.1117/12.913577

Cite this

Armijo, L. M., Brandt, Y. I., Withers, N. J., Plumley, J. B., Cook, N. C., Rivera, A. C., Yadav, S., Smolyakov, G. A., Monson, T., Huber, D. L., Smyth, H. D. C., & Osiński, M. (2012). Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8232) https://doi.org/10.1117/12.913577

@inproceedings{660695f885634000bebb721c7bfb1b5c,

title = "Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung",

abstract = "Iron oxide colloidal nanocrystals (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanocrystals to increase the effectiveness of inhalation aerosol antibiotics therapy through two mechanisms: directed particle movement in the presence of a static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm thereby increasing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Nanocrystals in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide-zinc selenide core-shell nanoparticles were prepared in parallel in order to allow imaging of the iron oxide nanoparticles. {\textcopyright} 2012 SPIE.",

author = "Armijo, \{Leisha M.\} and Brandt, \{Yekaterina I.\} and Withers, \{Nathan J.\} and Plumley, \{John B.\} and Cook, \{Nathaniel C.\} and Rivera, \{Antonio C.\} and Surabhi Yadav and Smolyakov, \{Gennady A.\} and Todd Monson and Huber, \{Dale L.\} and Smyth, \{Hugh D.C.\} and Marek Osi{\'n}ski",

year = "2012",

month = apr,

day = "2",

doi = "10.1117/12.913577",

language = "English",

isbn = "9780819488756",

volume = "8232",

booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung

AU - Armijo, Leisha M.

AU - Brandt, Yekaterina I.

AU - Withers, Nathan J.

AU - Plumley, John B.

AU - Cook, Nathaniel C.

AU - Rivera, Antonio C.

AU - Yadav, Surabhi

AU - Smolyakov, Gennady A.

AU - Monson, Todd

AU - Huber, Dale L.

AU - Smyth, Hugh D.C.

AU - Osiński, Marek

PY - 2012/4/2

Y1 - 2012/4/2

N2 - Iron oxide colloidal nanocrystals (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanocrystals to increase the effectiveness of inhalation aerosol antibiotics therapy through two mechanisms: directed particle movement in the presence of a static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm thereby increasing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Nanocrystals in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide-zinc selenide core-shell nanoparticles were prepared in parallel in order to allow imaging of the iron oxide nanoparticles. © 2012 SPIE.

AB - Iron oxide colloidal nanocrystals (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanocrystals to increase the effectiveness of inhalation aerosol antibiotics therapy through two mechanisms: directed particle movement in the presence of a static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm thereby increasing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Nanocrystals in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide-zinc selenide core-shell nanoparticles were prepared in parallel in order to allow imaging of the iron oxide nanoparticles. © 2012 SPIE.

UR - https://www.scopus.com/pages/publications/84859018863

U2 - 10.1117/12.913577

DO - 10.1117/12.913577

M3 - Conference contribution

SN - 9780819488756

VL - 8232

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -

Multifunctional superparamagnetic nanocrystals for imaging and targeted drug delivery to the lung

Abstract

Access to Document

Fingerprint

Cite this