Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

Leisha M. Armijo; Yekaterina I. Brandt; Antonio C. Rivera; Nathaniel C. Cook; John B. Plumley; Nathan J. Withers; Michael Kopciuch; Gennady A. Smolyakov; Dale L. Huber; Hugh D. Smyth; Marek Osinski

doi:10.1117/12.943621

Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

Leisha M. Armijo
, Yekaterina I. Brandt
, Antonio C. Rivera
, Nathaniel C. Cook
, John B. Plumley
, Nathan J. Withers
, Michael Kopciuch
, Gennady A. Smolyakov
, Dale L. Huber
, Hugh D. Smyth
, Marek Osinski

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Iron oxide colloidal nanoparticles (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanoparticles to increase the effectiveness of administering antibiotics through aerosol inhalation using two mechanisms: directed particle movement in the presence of an inhomogeneous static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm, thereby enhancing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanoparticles of various sizes and morphologies were synthesized and tested for specific losses (heating power). Nanoparticles in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide / zinc selenide core/shell nanoparticles were prepared, in order to enable imaging of the iron oxide nanoparticles. We also report on synthesis and characterization of MnSe/ZnSeS alloyed quantum dots. © 2012 SPIE.

Original language	English
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8548
DOIs	https://doi.org/10.1117/12.943621
State	Published - Dec 1 2012
Externally published	Yes

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10.1117/12.943621

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Armijo, L. M., Brandt, Y. I., Rivera, A. C., Cook, N. C., Plumley, J. B., Withers, N. J., Kopciuch, M., Smolyakov, G. A., Huber, D. L., Smyth, H. D., & Osinski, M. (2012). Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8548) https://doi.org/10.1117/12.943621

@inproceedings{90c0c6caaebb4c5185b555dcc07c6bb6,

title = "Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis",

abstract = "Iron oxide colloidal nanoparticles (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanoparticles to increase the effectiveness of administering antibiotics through aerosol inhalation using two mechanisms: directed particle movement in the presence of an inhomogeneous static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm, thereby enhancing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanoparticles of various sizes and morphologies were synthesized and tested for specific losses (heating power). Nanoparticles in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide / zinc selenide core/shell nanoparticles were prepared, in order to enable imaging of the iron oxide nanoparticles. We also report on synthesis and characterization of MnSe/ZnSeS alloyed quantum dots. {\textcopyright} 2012 SPIE.",

author = "Armijo, \{Leisha M.\} and Brandt, \{Yekaterina I.\} and Rivera, \{Antonio C.\} and Cook, \{Nathaniel C.\} and Plumley, \{John B.\} and Withers, \{Nathan J.\} and Michael Kopciuch and Smolyakov, \{Gennady A.\} and Huber, \{Dale L.\} and Smyth, \{Hugh D.\} and Marek Osinski",

year = "2012",

month = dec,

day = "1",

doi = "10.1117/12.943621",

language = "English",

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volume = "8548",

booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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T1 - Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

AU - Armijo, Leisha M.

AU - Brandt, Yekaterina I.

AU - Rivera, Antonio C.

AU - Cook, Nathaniel C.

AU - Plumley, John B.

AU - Withers, Nathan J.

AU - Kopciuch, Michael

AU - Smolyakov, Gennady A.

AU - Huber, Dale L.

AU - Smyth, Hugh D.

AU - Osinski, Marek

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Iron oxide colloidal nanoparticles (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanoparticles to increase the effectiveness of administering antibiotics through aerosol inhalation using two mechanisms: directed particle movement in the presence of an inhomogeneous static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm, thereby enhancing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanoparticles of various sizes and morphologies were synthesized and tested for specific losses (heating power). Nanoparticles in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide / zinc selenide core/shell nanoparticles were prepared, in order to enable imaging of the iron oxide nanoparticles. We also report on synthesis and characterization of MnSe/ZnSeS alloyed quantum dots. © 2012 SPIE.

AB - Iron oxide colloidal nanoparticles (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanoparticles to increase the effectiveness of administering antibiotics through aerosol inhalation using two mechanisms: directed particle movement in the presence of an inhomogeneous static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm, thereby enhancing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanoparticles of various sizes and morphologies were synthesized and tested for specific losses (heating power). Nanoparticles in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide / zinc selenide core/shell nanoparticles were prepared, in order to enable imaging of the iron oxide nanoparticles. We also report on synthesis and characterization of MnSe/ZnSeS alloyed quantum dots. © 2012 SPIE.

UR - https://www.scopus.com/pages/publications/84875732547

U2 - 10.1117/12.943621

DO - 10.1117/12.943621

M3 - Conference contribution

SN - 9780819492920

VL - 8548

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -

Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

Abstract

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