Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Elizabeth S. Levy; Demosthenes P. Morales; John V. Garcia; Norbert O. Reich; Peter C. Ford

doi:10.1039/c5cc07989f

Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Elizabeth S. Levy
, Demosthenes P. Morales
, John V. Garcia
, Norbert O. Reich
, Peter C. Ford

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.

Original language	English
Pages (from-to)	17692-17695
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	100
DOIs	https://doi.org/10.1039/c5cc07989f
State	Published - Jan 1 2015
Externally published	Yes

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title = "Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles",

abstract = "We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.",

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AU - Levy, Elizabeth S.

AU - Morales, Demosthenes P.

AU - Garcia, John V.

AU - Reich, Norbert O.

AU - Ford, Peter C.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.

AB - We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.

UR - https://www.scopus.com/pages/publications/84949484639

U2 - 10.1039/c5cc07989f

DO - 10.1039/c5cc07989f

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VL - 51

SP - 17692

EP - 17695

JO - Chemical Communications

JF - Chemical Communications

IS - 100

ER -

Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Abstract

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