Superparamagnetic relaxometry (SPMR) for sensitive detection of HER-2 positive tumors in mice

Giulio Paciotti; Kayla E. Minser; Caroline L. Weldon; Andrew Gomez; Todor Karaulanov; Helen J. Hathaway; William H. Anderson; Christopher P. Nettles; Dale L. Huber; Erika C. Vreeland

Superparamagnetic relaxometry (SPMR) for sensitive detection of HER-2 positive tumors in mice

Giulio Paciotti
, Kayla E. Minser
, Caroline L. Weldon
, Andrew Gomez
, Todor Karaulanov
, Helen J. Hathaway
, William H. Anderson
, Christopher P. Nettles
, Dale L. Huber
, Erika C. Vreeland

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Superparamagnetic relaxometry (SPMR) is a noninvasive technique that utilizes superconducting quantum interference device (SQUID) detectors to localize and quantify the magnetization of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) specifically bound to cancerous tumors. In an SPMR measurement, polyethylene glycol (PEG) coated NPs are functionalized with a tumor-targeting monoclonal antibody and injected intravenously. NPs that reach and bind to the target tissue are measured by the MRX™ instrument, while unbound nanoparticles, such as those freely circulating in the bloodstream, are not detected. Here, we demonstrate the use of SPMR for specific detection of HER2 positive tumors in mice using long-circulating anti-HER2 antibody conjugated PrecisionMRX® NPs in vitro and in vivo.

Original language	English
Title of host publication	Advanced Materials - TechConnect Briefs 2017
Pages	167-170
Number of pages	4
Volume	1
State	Published - Jan 1 2017
Externally published	Yes

Cite this

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title = "Superparamagnetic relaxometry (SPMR) for sensitive detection of HER-2 positive tumors in mice",

abstract = "Superparamagnetic relaxometry (SPMR) is a noninvasive technique that utilizes superconducting quantum interference device (SQUID) detectors to localize and quantify the magnetization of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) specifically bound to cancerous tumors. In an SPMR measurement, polyethylene glycol (PEG) coated NPs are functionalized with a tumor-targeting monoclonal antibody and injected intravenously. NPs that reach and bind to the target tissue are measured by the MRX{\texttrademark} instrument, while unbound nanoparticles, such as those freely circulating in the bloodstream, are not detected. Here, we demonstrate the use of SPMR for specific detection of HER2 positive tumors in mice using long-circulating anti-HER2 antibody conjugated PrecisionMRX{\textregistered} NPs in vitro and in vivo.",

author = "Giulio Paciotti and Minser, \{Kayla E.\} and Weldon, \{Caroline L.\} and Andrew Gomez and Todor Karaulanov and Hathaway, \{Helen J.\} and Anderson, \{William H.\} and Nettles, \{Christopher P.\} and Huber, \{Dale L.\} and Vreeland, \{Erika C.\}",

year = "2017",

month = jan,

day = "1",

language = "English",

isbn = "9780997511789",

volume = "1",

pages = "167--170",

booktitle = "Advanced Materials - TechConnect Briefs 2017",

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TY - GEN

T1 - Superparamagnetic relaxometry (SPMR) for sensitive detection of HER-2 positive tumors in mice

AU - Paciotti, Giulio

AU - Minser, Kayla E.

AU - Weldon, Caroline L.

AU - Gomez, Andrew

AU - Karaulanov, Todor

AU - Hathaway, Helen J.

AU - Anderson, William H.

AU - Nettles, Christopher P.

AU - Huber, Dale L.

AU - Vreeland, Erika C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Superparamagnetic relaxometry (SPMR) is a noninvasive technique that utilizes superconducting quantum interference device (SQUID) detectors to localize and quantify the magnetization of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) specifically bound to cancerous tumors. In an SPMR measurement, polyethylene glycol (PEG) coated NPs are functionalized with a tumor-targeting monoclonal antibody and injected intravenously. NPs that reach and bind to the target tissue are measured by the MRX™ instrument, while unbound nanoparticles, such as those freely circulating in the bloodstream, are not detected. Here, we demonstrate the use of SPMR for specific detection of HER2 positive tumors in mice using long-circulating anti-HER2 antibody conjugated PrecisionMRX® NPs in vitro and in vivo.

AB - Superparamagnetic relaxometry (SPMR) is a noninvasive technique that utilizes superconducting quantum interference device (SQUID) detectors to localize and quantify the magnetization of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) specifically bound to cancerous tumors. In an SPMR measurement, polyethylene glycol (PEG) coated NPs are functionalized with a tumor-targeting monoclonal antibody and injected intravenously. NPs that reach and bind to the target tissue are measured by the MRX™ instrument, while unbound nanoparticles, such as those freely circulating in the bloodstream, are not detected. Here, we demonstrate the use of SPMR for specific detection of HER2 positive tumors in mice using long-circulating anti-HER2 antibody conjugated PrecisionMRX® NPs in vitro and in vivo.

UR - https://www.scopus.com/pages/publications/85029410166

M3 - Conference contribution

SN - 9780997511789

VL - 1

SP - 167

EP - 170

BT - Advanced Materials - TechConnect Briefs 2017

ER -

Superparamagnetic relaxometry (SPMR) for sensitive detection of HER-2 positive tumors in mice

Abstract

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