Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene

Michael J. Geier; Eric G. Bowes; Graham M. Lee; Haoxin Li; Taryn O'Neill; Andrew Flewelling; Christopher M. Vogels; Andreas Decken; Christopher A. Gray; Stephen A. Westcott

doi:10.1002/hc.21072

Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene

Michael J. Geier
, Eric G. Bowes
, Graham M. Lee
, Haoxin Li
, Taryn O'Neill
, Andrew Flewelling
, Christopher M. Vogels
, Andreas Decken
, Christopher A. Gray
, Stephen A. Westcott

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A family of arylspiroborate compounds has been prepared from 2,3-dihydroxynaphthalene and characterized fully using multinuclear NMR spectroscopy and elemental analyses. Single crystal X-ray diffraction studies were carried out on the tetramethylammonium (4) and calcium (6) derivatives. Compound 6 represents the first structurally characterized example of a calcium arylspiroborate salt. All compounds showed modest antifungal and antimycobacterial activities. These results have revealed a new class of compounds that should be further developed to design more potent and selective antitubercular agents.

Original language	English
Pages (from-to)	116-123
Number of pages	8
Journal	Heteroatom Chemistry
Volume	24
Issue number	2
DOIs	https://doi.org/10.1002/hc.21072
State	Published - Mar 2013
Externally published	Yes

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title = "Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene",

abstract = "A family of arylspiroborate compounds has been prepared from 2,3-dihydroxynaphthalene and characterized fully using multinuclear NMR spectroscopy and elemental analyses. Single crystal X-ray diffraction studies were carried out on the tetramethylammonium (4) and calcium (6) derivatives. Compound 6 represents the first structurally characterized example of a calcium arylspiroborate salt. All compounds showed modest antifungal and antimycobacterial activities. These results have revealed a new class of compounds that should be further developed to design more potent and selective antitubercular agents.",

author = "Geier, \{Michael J.\} and Bowes, \{Eric G.\} and Lee, \{Graham M.\} and Haoxin Li and Taryn O'Neill and Andrew Flewelling and Vogels, \{Christopher M.\} and Andreas Decken and Gray, \{Christopher A.\} and Westcott, \{Stephen A.\}",

year = "2013",

month = mar,

doi = "10.1002/hc.21072",

language = "English",

volume = "24",

pages = "116--123",

journal = "Heteroatom Chemistry",

issn = "1042-7163",

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T1 - Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene

AU - Geier, Michael J.

AU - Bowes, Eric G.

AU - Lee, Graham M.

AU - Li, Haoxin

AU - O'Neill, Taryn

AU - Flewelling, Andrew

AU - Vogels, Christopher M.

AU - Decken, Andreas

AU - Gray, Christopher A.

AU - Westcott, Stephen A.

PY - 2013/3

Y1 - 2013/3

N2 - A family of arylspiroborate compounds has been prepared from 2,3-dihydroxynaphthalene and characterized fully using multinuclear NMR spectroscopy and elemental analyses. Single crystal X-ray diffraction studies were carried out on the tetramethylammonium (4) and calcium (6) derivatives. Compound 6 represents the first structurally characterized example of a calcium arylspiroborate salt. All compounds showed modest antifungal and antimycobacterial activities. These results have revealed a new class of compounds that should be further developed to design more potent and selective antitubercular agents.

AB - A family of arylspiroborate compounds has been prepared from 2,3-dihydroxynaphthalene and characterized fully using multinuclear NMR spectroscopy and elemental analyses. Single crystal X-ray diffraction studies were carried out on the tetramethylammonium (4) and calcium (6) derivatives. Compound 6 represents the first structurally characterized example of a calcium arylspiroborate salt. All compounds showed modest antifungal and antimycobacterial activities. These results have revealed a new class of compounds that should be further developed to design more potent and selective antitubercular agents.

UR - https://www.scopus.com/pages/publications/84875216007

U2 - 10.1002/hc.21072

DO - 10.1002/hc.21072

M3 - Article

SN - 1042-7163

VL - 24

SP - 116

EP - 123

JO - Heteroatom Chemistry

JF - Heteroatom Chemistry

IS - 2

ER -

Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene

Abstract

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